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Web developers seeking to deploy Python web applications have several good options at their disposal, but Gunicorn and uWSGI are two of the most popular and powerful choices. Both serve as Web Server Gateway Interface (WSGI) servers, which act as the middlemen between web applications written in Python and the web server itself. Here’s a comprehensive guide on setting up a WSGI server using Gunicorn and uWSGI, to help you deploy your web applications efficiently and manage web traffic effectively. Before diving into the specifics, it’s crucial to understand what WSGI really is. WSGI is a specification that describes how a web server communicates with web applications.